王晓珂  副教授

医学博士，澳网官方网站副教授，硕士生导师。2011年获得华中科技大学澳网官方网站医学博士学位，同年入职澳网官方网站（中国）股份有限公司；2014至2016年进入美国马里兰大学医学院进行博士后工作；目前就职于澳网官方网站（中国）股份有限公司职业医学与环境卫生学系。本人主要从事环境颗粒物和重金属暴露对肥胖、糖尿病和非酒精性脂肪肝等慢性病的影响及相关分子机制研究。近年来，先后主持了国家自然科学基金青年基金、江苏省自然科学基金青年基金和江苏省高校自然科学基金面上项目等多项课题；以第一作者和通讯作者身份在《toxicological sciences》、《particle and fibre toxicology》和《Toxicology Letters》等期刊发表SCI论文数篇，其中JCR二区及以上论文5篇；实审专利1项。

招生方向：

环境毒理

代表论文：

1.Wang X. K., Yang Y. X., Zhu P. Y., Wu Y. F., Jin Y., Yu S. L., Wei H. Y., Qian M. Z., Cao W. M., Xu S. Y., Liu Y. Q., Chen G., and Zhao X. Y., Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. Environmental Pollution, 2019. 255.  IF=5.714  JCR二区

2.Wang X. K., Zhu P. Y., Xu S. Y., Liu Y. T., Jin Y., Yu S. L., Wei H. Y., Li J. L., Zhang Q. L., Hasegawa T., Yao C. J., Yoshimura H., Wu Q. Y., and Zhao X. Y., Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. International Journal of Biochemistry & Cell Biology, 2019. 114.  IF=3.144  JCR三区

3.Wei H. Y., Hu Q. Y., Wu J. X., Yao C. J., Xu L. F., Xing F. J., Zhao X. Y., Yu S. L., Wang X. K., and Chen G., Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus. Biochemical and Biophysical Research Communications, 2018. 504(2): 393-399. IF=2.705  JCR三区

4.Zhao X. Y., Jin Y., Yang L. J., Hou Z. X., Liu Y. Q., Sun T. Y., Pei J. X., Li J. L., Yao C. J., Wang X. K., and Chen G., Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicology Letters, 2018. 296: 73-81. IF=3.499  JCR二区

5.Wang X. K., Chen M., Zhong M., Hu Z., Qiu L., Rajagopalan S., Fossett N. G., Chen L. C., and Ying Z., Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila. Toxicol Sci, 2017. 156(1): 199-207. IF=3.564  JCR二区

6.Chen M. J.#, Wang X. K. #, Hu Z. Y., Zhou H. F., Xu Y. Y., Qiu L. L., Qin X. B., Zhang Y. H., and Ying Z. K., Programming of mouse obesity by maternal exposure to concentrated ambient fine particles. Particle and Fibre Toxicology, 2017. 14.  IF=6.561  JCR一区

7.Yu S. L., Xu L. F., Wu J. X., Yao C. J., Hu Q. Y., Zhang C. X., Zhao X. Y., Wei H. Y., Wang X. K.*, and Chen G.*, Increased PIT1 and PIT2 Expression in Streptozotocin (STZ)-induced Diabetic Mice Contributes to Uptake of iAs((V)). Biomedical and Environmental Sciences, 2017. 30(11): 792-801. IF=1.967  JCR三区

8.Wang X. K., Cheng M. J., Zhao M., Ge A. G., Guo F. F., Zhang M., Yang Y. H., Liu L. G., and Yang N. H., Differential effects of high-fat-diet rich in lard oil or soybean oil on osteopontin expression and inflammation of adipose tissue in diet-induced obese rats. European Journal of Nutrition, 2013. 52(3): 1181-1189. IF=4.449  JCR二区

科研项目：

获得奖项：

2017. 澳网官方网站本科教学工作审核评估先进

2018. 南通市高层次人才工程“226高层次人才培养工程”第三层次培养对象

2019. 2018年    澳网官方网站“优秀本科毕业论文”指导教师