赵新元  副教授

赵新元: 男，1987年10月生，医学博士，澳网官方网站澳网官方网站副教授，硕士生导师，任南通市环境毒理学重点实验室常务副主任、环境与环境研究团队负责人、职业医学与环境毒理学系系主任。入选江苏省高校青蓝工程、中国毒理学会青年委员、中国环境诱变剂学会致突变专委会青年委员、江苏省预防医学会职业健康专委会常务委员、南通市医学会生殖医学分会副主任委员。2018年9月起开始为期一年的访学研究（日本德岛大学）。2020年在国家自然科学基金委医学部挂职锻炼一年。

主要从事环境毒理学研究，具体研究方向：纳米材料的呼吸毒性研究、重金属的呼吸毒性和神经毒性研究等。第一完成人获得江苏省高校科学技术研究成果奖、获得江苏省三下乡先进工作者、南通市创业创新大赛二等奖、澳网官方网站优秀教育工作者和优秀班主任等荣誉称号。近5年来，主持包括国家自然科学基金等科研项目共8项，主持教改课题2项，指导6项老员工创新训练计划，指导本科生发表论文15篇（其中本科生一作5篇）。发表SCI论文40余篇，其中第一作者和通讯作者27篇（IF>10一篇，IF>5十三篇）。第一完成人获批软件著作权一项，申报发明专利两项。

招生方向：

劳动卫生与环境卫生学、卫生毒理学

代表论文：

1. Xinyuan Zhao^#, Saisai Wei^#, Zhijian Li, Chen Lin, Zhenfeng Zhu, Desen Sun, Rongpan Bai, Jun Qian, Xiangwei Gao*, Guangdi Chen*, Zhengping Xu*. Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis. Cell death and Disease. 2019, 10:127.

2. Xinyuan Zhao^#, Yiming Liu^#, Ganlin Zhu, Yuanyuan Liang, Bo Liu, Yifan Wu, Muxi Han, Wenxing Sun, Yu Han, Gang Chen, Junkang Jiang*. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. Science of The Total Environment. 2019, 646(1): 1047-1055.

3. Xinyuan Zhao^#,*, Yifan Wu^#, Jinlong Li, Dongyu Li, Yang Jin, Piaoyu Zhu, Yingqi Liu, Yin Zhuang, Shali Yu, Weiming Cao, Haiyan Wei, Xiaoke Wang, Yu Han*, Gang Chen*. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology. 2019, 423: 42-53.

4. Xinyuan Zhao^#, Yang Jin^#, Lijia Yang, Zhengxing Hou, Yingqi Liu, Tianyu Sun, Jiaxin Pei, Jinlong Li, Chenjuan Yao, Xiaoke Wang*, Gang Chen*. Promotion of SIRT1 protein degradation and lower SIRT1 gene expression via reactive oxygen species is involved in Sb-induced apoptosis in BEAS-2b cells. Toxicology Letters. 2018, 296: 73-81.

5. Xinyuan Zhao, Fengjun Xing, Yewen Cong, Yin Zhuang, Muxi Han, Zhiqiang Wu, Shali Yu, Haiyan Wei, Xiaoke Wang*, Gang Chen*. Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells. The International Journal of Biochemistry and Cell Biology. 2017, 93(12): 32-40.

6. Xinyuan Zhao, Lifeng Yin, Yifan Wu, Muxi Han, Yin Zhuang, Yewen Cong, Yiming Liu, Gang Chen, Junkang Jiang*. Manganese induces neuroinflammation via NF-kB/ROS NLRP3 pathway in rat brain striatum and HAPI cells. Molecular & Cellular Toxicology. 2019, 15: 173-183.

7. ZHAO Xinyuan, FANG Wenpan, Lin Chen, Chen Guangdi*. Association of Exposure to Extremely Low Frequency Electromagnetic Fields with Adverse Birth Outcomes. High Voltage Engineering. 2015, 41(4): 1383-1389.

8. Dongyu Li^#, Xinyuan Zhao^#, Wei Qin, Hequn Zhang, Yue Fei, Liwei Liu, Ken-Tye Yong, Guangdi Chen*, Ben Zhong Tang*, Jun Qian*. Toxicity Assessment and Long-term Three photon Fluorescence Imaging of Bright AIE Nanodots in Zebrafish. Nano Research. 2016，9(7):1921-1933. ^# co-first author

9. Chen Lin^#, Xinyuan Zhao^#, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu*, Xiangwei Gao*. Transcriptional activation of Follistation by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress. Scientific Reports. 2016, Feb 16; 6:21133. ^# co-first author

10. Li jiang^#, Xinyuan Zhao^#, Yu Fei, Dongdong Yu, Jun Qian, Jinguang Tong, Guangdi Chen*, Sailing He*. The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution. Scientific Reports. 2016, Apr 28; 6:25111. ^# co-first author

11. Chunyan Huang^#, Xinyuan Zhao^#, Yan Lu, Linchi Wang, Yihe Hu, Jun Zhang, Qiaoliang Huang, Gang Chen*. Changes in life expectancy from 2006 to 2015 in Suzhou, East China: contribution of Age- and Cause-specific Mortality. Asia-Pacific Journal of Public Health. 2018, 30(1): 75-84. ^# co-first author

通讯作者：

1. Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen*, Xinyuan Zhao*. p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation. Journal of nanobiotechnology. 2020, 18:77. *corresponding author.

2. Weiwei Shi, Yanfen Tang, Ye Zhi, Zhijie Li, Shali Yu, Junkang Jiang, Jinfeng Zhu, Jinlong Li, Junkang Jiang, Feng Wang*, Liling Su*, Xinyuan Zhao*. Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity. Science of The Total Environment. 2020, 737: 140252. *corresponding author.

3. Shenya Xu, Zeyun Yang, Ye Zhi, Shali Yu, Tao Zhang, Junkang Jiang, Jun Tang, Hongsen He, Ming Lu, Xiaoke Wang*, Qiyun Wu*,Xinyuan Zhao*. The effects of antimony on Alzheimer’s disease-like pathological changes in mice brain. Science of the Total Environment. 2021,760: 143235.*corresponding author.

4. Ganlin Zhu^#, Yiming Liu^#, Ye Zhi, Yang Jin, Jinlong Li*, Weiwei Shi, Yuting Liu, Yu Han, Shali Yu, Junkang Jiang*, Xinyuan Zhao*. PKA- and Ca²⁺ -dependent p38MAPK/CREB activation protects against manganese-mediated neuronal apoptosis. Toxicology Letters. 2019, 309: 10-19. *corresponding author.

5. Changyue Wu, Yifan Wu, Yang Jin, Piaoyu Zhu, Weiwei Shi, Jinlong Li, Qinyun Wu, Qinglin Zhang*, Yu Han*, Xinyuan Zhao*. Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis. RSC Advances. 2019, 9, 13855-13862. *corresponding author.

6. Man Jiao^#, Kaizhi Yin^#, Tao Zhang, Changyue Wu, Yan Zhang, Xinyuan Zhao*, Qinyun Wu*. Effects of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death. Chemosphere. 2019, 226: 678-686. *corresponding author.

7. Dongyu Li, Li Xue, Zhenfeng Zhu, Xinyuan Zhao*, Jun Qian*. Graphene oxide nanoparticles for two-photon fluorescence imaging of zebrafish. Optical and Quantum Electronics. 2016, 48(11): 519 *corresponding author.

8. Changyue Wu, Kaizhi Yin, Yan Zhang, Man Jiao, Xinyuan Zhao*, Qiyun Wu*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway. Biomedical and Environmental Sciences. 2019, 32(4): 281-290. *corresponding author.

9. Xiaoke Wang^#, Piaoyu Zhu^#, Shenya Xu, Yuting Liu, Yang Jin, Shali Yu, Haiyan Wei, Jinlong Li, Qinglin Zhang, Takahiro Hasegawa, Chenjuan Yao, Hiroshi Yoshimura, Qiyun Wu, Xinyuan Zhao*. Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway. The International Journal of Biochemistry and Cell Biology. 2019, 114(9). *corresponding author.

10. Xiaoke Wang^#, Yuxue Yang^#, Piaoyu Zhu, Yifan Wu, Yang Jin, Shali Yu, Haiyan Wei, Muzhou Qian, Weiming Cao, Shenya Xu, Yingqi Liu, Gang Chen, Xinyuan Zhao*. Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. Environmental Pollution. 2019, 255:113366. *corresponding author.

11. Liling Su, Longtao Zhu, Zhenchao Liu, Jianyao Lou, Bing Han, Chen Lin, Dongyu Li, Jun Qian, Xinyuan Zhao*, Guangdi Chen*. The decreased permittivity of zebrafish embryos culture medium by magnetic fields did not affect early development of zebrafish embryos. Ecotoxicology and Environmental Safety. 2020, 193: 110350. *corresponding author.

12. Tao Zhang, Yudan Zheng , Man Jiao, Zhi Ye, Shenya Xu, Piaoyu Zhu, Xinyuan Zhao*, Qiyun Wu*. Nuclear Factor-kB Signaling Mediates Antimony-induced Astrocyte Activation. Biomedical and Environmental Sciences. 2021, 34(1): 29-39. *corresponding author.4000

13. Yudan Zheng, Wenjie Ding, Tao Zhang, Zixuan Zhao, Rui Wang, Zhjie Li, Shali Yu, Jinlong Li, Xinyuan Zhao*, Qiyun Wu*. Antimony-induced astrocyte activation via mitogen-activated protein kinase activation-dependent CREB phosphorylation. Toxicology Letters. 2021, 352: 9-16. *corresponding author.

14. Wenyi Zhang, Ting Chen, Jun Liu, Shali Yu, Lei Liu,Miaosen Zheng, Yifei Liu, Hongbing Zhang*, Tingting Bian*, Xinyuan Zhao*. RAB11F1P1: An Indicator for Tomor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics. Frontiers in Genetics. 2021, 12: 757169. *corresponding author.

15. Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang*, Xinyuan Zhao*. GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis. Ecotoxicology and Environmental Safety. 2022, 234: 113413. *corresponding author.

16. Wenyi Zhang, Pei Xiao, Jiayi Tang, Rui Wang, Xiangdong Wang, Fengxu Wang, Junpu Ruan, Shali Yu, Juan Tang, Rongrong Huang*, Xinyuan Zhao*. m6A Regulator-Mediated Tumor Infiltration and Methylation Modification in Cervical Cancer Microenvironment. Frontiers in Immunology. 2022, 888650. *corresponding author.

17. 王瑞，刘蕾，邱红梅，赵新元*. 纳米二氧化硅影响自噬的机制及其生物学意义的研究进展. 重庆医学，2022，51（5）：874-879. (通讯作者)

18. 于莎莉，陈刚，王晓珂，韦海燕，唐娟，赵新元*. 综合设计性实验教学法在《环境卫生学》实验教学中的应用. 交通医学，2021，35（3）：317-318. (通讯作者)

19. 韩沐汐，杨晋娴，吴依帆，朱飘雨，金杨，陈刚，赵新元*. 氯化锑对斑马鱼胚胎发育的影响. 毒理学杂志，2018，32（6）：447-451. (通讯作者)

科研项目：

1. 国家自然科学基金面上项目，82173554，纳米二氧化硅通过下调SIRT1碱化肺泡上皮细胞溶酶体及诱导肺纤维化，2022/01-2025/12，55万，在研，主持。

2. 国家自然科学基金青年项目，81703255，肺泡上皮细胞p62聚集在超细颗粒物诱导肺纤维化中的作用及机制研究，2018/01-2020/12，20万，结题，主持。

3. 江苏省自然科学基金面上项目，SIRT1降解在纳米二氧化硅诱导肺泡上皮细胞溶酶体碱化及肺纤维化中的作用和机制，2020/07-2023/06，10万，在研，主持。

4. 江苏省高校“青蓝工程”，优秀青年骨干教师，2020/05-2023/05，4万，在研。

5. 南通市社会发展科技计划项目，MS12017014-8，靶向加快自噬流在颗粒物诱导肺损伤中的预防作用及机制研究，2017/07-2019/07，4万，结题，主持。

6. 南通市基础科学研究项目，JC2019027，基于Wnt通路评估一种新神经毒物-锑的阿尔茨海默病致病风险， 2019.07-2021.06，3万，结题，主持。

7. 自噬在锑引起A549细胞损伤中的作用及机制，澳网官方网站引进人才项目，2017/04-2019/04，4万，结题，主持。

8. 校级教改课题，基于实践技能导向的《环境卫生学》实验教学改革研究，2018/09-2020/06，0.3万，结题，主持。

9. 澳网官方网站大型仪器设备开放基金，2020年，0.5万，结题，主持。

10. 校级教改课题，《环境卫生学》课程试题库建设项目，2018/01-2018/12，结题，主持。

获得奖项：

1、大气污染物经呼吸道暴露的损伤效应及机制（2021年），江苏省高校科学技术研究成果奖，三等奖，第一完成人。

2、南通市第十二届自然科学优秀学术论文优秀论文奖（2021年），排序第一。

3、南通市科技创业大赛（2019年）二等奖，指导教师。

4、澳网官方网站（中国）股份有限公司青年教师讲课比赛一等奖（2021年）。